Table 1.
Top 20 genes differentially expressed in response to young and old serum.
| Gene | Name | P value |
|---|---|---|
| ISCA1 | Iron-sulfur cluster assembly | 0.000065 |
| ANXA2 | Annexin A2 | 0.00014 |
| ATP6AP1 | ATPase, H+ transporting, lysosomal accessory protein 1 | 0.0004 |
| ARPP19 | cAMP-regulated phosphoprotein 19 | 0.0004 |
| PFTK1 | Serine/threonine-protein kinase PFTAIRE-1 | 0.00049881 |
| TUBB | Tubulin, beta | 0.0006 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.001035752 |
| PPAP2A | Phosphatidic acid phosphatase type 2A | 0.00107 |
| ABTB1 | Ankyrin repeat and BTB (POZ) domain containing 1 | 0.001171827 |
| TMEM149 | Transmembrane protein 149 | 0.001187346 |
| ZC4H2 | Zinc finger, C4H2 domain containing | 0.001198645 |
| C3ORF72 | Chromosome 3 open reading frame 72 | 0.001283206 |
| ZNF264 | Zinc finger protein 264 | 0.0013 |
| IFIT3 | Interferon-induced protein with tetratricopeptide repeats 3 | 0.0013 |
| ZMYM2 | Zinc finger, MYM-type 2 | 0.0013 |
| ZDHHC6 | Zinc finger, DHHC-type containing 6 | 0.001367863 |
| ENDOG | Endonuclease G | 0.0017 |
| OTUD4 | OTU domain containing 4 | 0.001696685 |
| PRDX3 | Peroxiredoxin 3 | 0.001814213 |
| TRIM45 | TRIM45 tripartite motif-containing 45 | 0.001920272 |
141 probes reached a significance threshold P value of < 0.01 (uncorrected for multiple comparisons) for differential expression at one or more of the 5 time-points (1, 6, 24, 72 and 144 hours) following exposure to young or old serum.