Table 1: Disparate networks of disease associated microbe revealed with age and injury.

The predominance of bacterial shifts seen in the heatmap (Figure 3) have published links to pathology of the brain-gut axis. Listed here are the names of bacterial species that were altered in mice with age and injury. The data is presented in conjunction with pathological processes associated with similar changes seen in the literature. Contrast of aged shams with young sham revealed aged mice to have the largest shift of bacterial species. Comparison with of young and aged injured animals to their respective sham groups reveal the dissimilar yet pernicious expression of bacterial species of linked to BGA dysfunction.

Disease associated microbial network in aged sham	BGA Associated Disease	Disease associated microbial network in young TBI	BGA Associated Disease	Disease associated microbial network in aged TBI	BGA Associated Disease
Dorea	Inflammatory Bowel Syndrome(IBS),Mult iple Sclerosis(MS)	Methylpentosum	SI	Jeotgalicoccus psychrophilus	Uncharacterized species
Butyricicoccus pullicaecorum	Ulcerative Colitis (UC) and Crohn's Disease (CD)	Allobaculum	AD	Lactobacilus reuteri	Metabolic Probiotic (MP)
Allobaculumx	Alzheimer’s Disease (AD)	Clostridium clocleatum	SI
Candidatus Arthromitus	Systemic Inflammation (SI)	Anaerostipes	Gut Dysbiosis (GD)
Streptococus, Clostridium	Traumatic Brain Injury (TBI)	Lactobacillus, Turiobbacter	IBD
Bacteroidetes	Metabolic Disease (MD), (AD)	Coprococus	Parkinson’s Disease (PD)
Bacteroides	MD, AD
Parabacteriodetes gordonii	Inflammatory Bowel Disease (IBD), UC
Prevotella	SI
Bacteroides ovatus	MD, AD
Underrepresented Microbial Species		Underrepresented Microbial Species		Underrepresented Microbial Species
Staphylococcus succinus	Attenuates Inflammation			Candidatus arthromitus	MP
Clostridium	Attenuates depression, Enteritis			Bacteroidetes	MP, AD
Clostridium Cocleatum	Colitis			Anaerostipes	MD