Table 3.
Comparison of multiple regression model parameters for models using the classification of interneurons by axonal morphology
| Model 7 | Model 8 | Model 9 | Model 10 | Model 11 | Model 12 | Model 13 | |
|---|---|---|---|---|---|---|---|
| Intercept | 7.3 ± 2.2, p = 0.0017* | −12.5 ± 7.5, p = 0.11 | −13.6 ± 7.8, p = 0.087 | −13.7 ± 7.7, p = 0.085 | - 11.4 ± 7.7, p = 0.15 | 0.68 ± 11.1, p = 0.95 | 17.9 ± 19.4, p = 0.36 |
| Age | -- | 0.34 ± 0.14, p = 0.022* | 0.35 ± 0.14, p = 0.020* | 0.37 ± 0.15, p = 0.016* | 0.29 ± 0.15, p = 0.065 | 0.43 ± 0.16, p = 0.011* | 0.46 ± 0.17, p = 0.013* |
| Sex (male = 1) | -- | 2.8 ± 2.5, p = 0.27 | 3.2 ± 2.6, p = 0.23 | 2.7 ± 2.9, p = 0.36 | 4.6 ± 2.8, p = 0.12 | −1.2 ± 3.3, p = 0.72 | 3.1 ± 4.2, p = 0.47 |
| Rosehip | 8.3 ± 3.6, p = 0.024* | 8.7 ± 3.4, p = 0.014* | 9.1 ± 3.7, p = 0.019* | 9.8 ± 3.6, p = 0.009* | 8.3 ± 3.6, p = 0.025* | 9.3 ± 3.8, p = 0.018* | 8.8 ± 4.1, p = 0.039* |
| Neurogliaform | −1.9 ± 3.5. p = 0.59 | −0.52 ± 3.4, p = 0.88 | -- | 0.039 ± 3.5, p = 0.99 | −0.15 ± 3.7, p = 0.97 | −0.63 ± 3.6, p = 0.86 | 0.88 ± 4.0, p = 0.83 |
| Layer 2/3 innervating | 11.0 ± 3.7, p = 0.0050* | 11.6 ± 3.5, p = 0.0017** | 12.0 ± 4.0, p = 0.0043** | 12.1 ± 3.5, p = 0.0015** | 14.4 ± 3.9, p = 0.00076** | 14.2 ± 3.7, p = 0.00046*** | 16.7 ± 4.2, p = 0.00038*** |
| Stalked boutons | −2.0 ± 4.1, p = 0.63 | −3.2 ± 3.9, p = 0.41 | −2.9 ± 4.2, p = 0.50 | −2.1 ± 4.1, p = 0.61 | −0.45 ± 4.4, p = 0.92 | −1.5 ± 4.0, p = 0.70 | 0.48 ± 4.5, p = 0.92 |
| Other | -- | -- | −1.6 ± 4.7, p = 0.74 | -- | -- | -- | -- |
| Not recovered | -- | -- | 1.3 ± 3.7, p = 0.72 | -- | -- | -- | -- |
| Temporal lobe epilepsy | -- | -- | -- | 2.7 ± 4.5, p = 0.56 | -- | -- | 0.39 ± 12.7, p = 0.98 |
| Glioblastoma | -- | -- | -- | −1.7 ± 2.9, p = 0.56 | -- | -- | −9.2 ± 4.2, p = 0.038* |
| Cortical infiltration (MRI) | -- | -- | -- | -- | 4.2 ± 3.3, p = 0.21 | -- | 1.9 ± 6.8, p = 0.78 |
| Hemisphere (left = 1) | -- | -- | -- | -- | 0.045 ± 3.2, p = 0.99 | -- | 2.6 ± 4.4, p = 0.56 |
| Frontal | -- | -- | -- | -- | −2.7 ± 2.8, p = 0.35 | -- | 0.64 ± 5.3, p = 0.90 |
| Parietal | -- | -- | -- | -- | −4.9 ± 5.3, p = 0.36 | -- | −11.8 ± 6.9, p = 0.096 |
| Seizures in year prior to surgery | -- | -- | -- | -- | -- | −7.7 ± 4.2, p = 0.076 | −15.7 ± 6.0, p = 0.014* |
| Seizures more than a year ago | -- | -- | -- | -- | -- | 4.5 ± 4.5, p = 0.33 | −4.1 ± 7.0, p = 0.56 |
| Dexamethasone presurgery | -- | -- | -- | -- | -- | −2.8 ± 3.9, p = 0.48 | −3.5 ± 9.7, p = 0.72 |
| Dexamethasone at time of surgery | -- | -- | -- | -- | -- | −7.3 ± 4.1, p = 0.081 | −14.2 ± 9.5, p = 0.15 |
| Levetiracetam | -- | -- | -- | -- | -- | −7.9 ± 4.1, p = 0.059 | −15.4 ± 6.5, p = 0.024* |
| df | 43 | 41 | 40 | 39 | 37 | 36 | 30 |
| Residual sum of squares | 3080 | 2554 | 2528 | 2476 | 2350 | 2111 | 1693 |
| R2 (COD) | 0.29 | 0.41 | 0.42 | 0.43 | 0.46 | 0.52 | 0.61 |
| Adj. R2 | 0.23 | 0.33 | 0.32 | 0.32 | 0.32 | 0.37 | 0.39 |
| ANOVA | |||||||
| F | 4.5 | 4.8 | 4.2 | 3.7 | 3.2 | 3.5 | 2.8 |
| p | 0.0041** | 0.00081** | 0.0016* | 0.0026** | 0.0050* | 0.0022** | 0.0069* |
The dependent variable is tonic current. All independent variables are given in the first column. Coefficients for each model are given in pA along with SEs and with the associated p values given below in italics. Summary statistics for each model are given at the bottom of the table. For sex and hemisphere, coefficients were arbitrarily calculated such that they represent the predicted change in tonic amplitude if the patient was male or the tissue was taken from the left hemisphere, respectively.