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. Author manuscript; available in PMC: 2022 Apr 7.
Published in final edited form as: Nat Aging. 2021 Oct 7;1(10):870–879. doi: 10.1038/s43587-021-00121-8

Figure 1. Senescent Cell Accumulation Positive Feedback Loop.

Figure 1.

Cellular senescence is induced following exposure to an initial stress. The resulting senescent cells produce a SASP that can potentiate further senescence cell accumulation and impair clearance. In turn, the SASP can be amplified eliciting an environment of chronic inflammation and additional senescence inducing stressors that drive a feed-forward cycle of senescent cell accumulation.