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. 2021 Nov 10;19(11):e3001447. doi: 10.1371/journal.pbio.3001447

Fig 8. Postnatal GYS1 deletion leads to whole-body metabolic alterations and cardiac dysfunction.

Fig 8

Gys1Myh6Cre or Myh6-Cre (control) mice were IP injected with 62.5 mg/kg tamoxifen at PD1, PD2, and PD3, and killed at PD14. (A) Immunoblot showing partial GYS1 deletion in heart extracts. (B) Heart glycogen content. (C) Echocardiography-measured FS. (D) NEFA plasma levels. (E) Blood plasma glucose in fed or fasted (e.g., food deprived for 4 h) conditions. (F, G) BAT temperature chart and representative thermographic images mice at PD14. Data are mean ± SEM (n = 3–17). *p < 0.05; **p < 0.01; ***p < 0.001 by Student t test or two-way ANOVA coupled to Tukey posttest. Raw data are given in S14 Fig. BAT, brown adipose tissue; FS, fractional shortening; GYS1, glycogen synthase 1; NEFA, non-esterified fatty acid.