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. 2021 Nov 25;139(8):1222–1233. doi: 10.1182/blood.2021013422

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The microfluidic device for trapping NETs in human blood. (A) Structures of RvTs used in these experiments. RvT1: 7S,13R,20S-trihydroxy-8E,10Z,14E,16Z,18E-docosapentaenoic acid; RvT2: 7S,12R,13S-trihydroxy-8Z,10E,14E,16Z,19Z-docosapentaenoic acid; RvT3: 7S,8R,13S-trihydroxy-9E,11E,14E,16Z,19Z-docosapentaenoic acid; and RvT4: 7S,13R- dihydroxy-8E,10Z,14E,16Z,19Z-docosapentaenoic acid. (B) Overview of the microfluidic NET-capturing device. Each device consists of an inlet reservoir (for loading samples [eg, human blood]), micropost islands (for capturing NETs), and an outlet connected via Tygon Tubing to a syringe pump; flow rate was set at 10 µL/min with a target volume of 50 µL. The scheme illustrates a device in the absence or presence of human blood. Each device contains 45 micropost islands, and each island is formed by an array of 104 microposts.