Table 2.
Association between SOCS3 rs8064821 C>A polymorphism and hypertension risk in Guangxi Province.
| Models | Genotypes | Control, n = 279 (%) | Hypertension, n = 248 (%) | Unadjusted OR (95% CI) | P value | Adjusted OR∗ (95% CI) | Adjusted P value∗ |
|---|---|---|---|---|---|---|---|
| rs8064821 C>A | HWE = 0.374 | HWE = 0.812 | |||||
| Additive | CC | 171 (61.3) | 127 (51.2) | 1.00 (reference) | 1.00 (reference) | ||
| CA | 98 (35.1) | 102 (41.1) | 1.401 (0.978-2.009) | 0.066 | 2.647 (1.391-5.038) | 0.003 | |
| AA | 10 (3.6) | 19 (7.7) | 2.558 (1.150-5.690) | 0.021 | 5.776 (1.613-20.682) | 0.007 | |
| Dominant | CC | 171 (61.3) | 127 (51.2) | 1.00 (reference) | 1.00 (reference) | ||
| CA/AA | 108 (38.7) | 121 (48.8) | 1.509 (1.067-2.133) | 0.020 | 2.943 (1.584-5.466) | 0.001 | |
| Recessive | CC/CA | 269 (96.4) | 229 (92.3) | 1.00 (reference) | 1.00 (reference) | ||
| AA | 10 (3.6) | 19 (7.7) | 2.232 (1.017-4.897) | 0.045 | 3.729 (1.119-12.426) | 0.032 |
OR: odds ratio; CI: confidence interval. ∗Adjusted for age, gender, BMI, smoking history, FBG, and dyslipidemia.