Table 3.
Association between S0CS3 rs8064821 C>A polymorphism and hypertension risk in Shandong Province.
| Models | Genotypes | Control, n = 290 (%) | Hypertension, n = 274 (%) | Unadjusted OR (95% CI) | P value | Adjusted OR∗ (95% CI) | Adjusted P value∗ |
|---|---|---|---|---|---|---|---|
| rs8064821 C>A | HWE = 0.607 | HWE = 0.654 | |||||
| Additive | CC | 187 (64.5) | 146 (53.3) | 1.00 (reference) | 1.00 (reference) | ||
| CA | 90 (31.0) | 110 (40.1) | 1.565 (1.100-2.228) | 0.013 | 1.965 (1.210-3.191) | 0.006 | |
| AA | 13 (4.5) | 18 (6.6) | 1.773 (0.841-3.738) | 0.132 | 1.264 (0.456-3.502) | 0.653 | |
| Dominant | CC | 187 (64.5) | 100 (38.0) | 1.00 (reference) | 1.00 (reference) | ||
| CA/AA | 103 (35.5) | 163 (62.0) | 1.592 (1.135-2.232) | 0.007 | 1.854 (1.166-2.947) | 0.009 | |
| Recessive | CC/CA | 277 (95.5) | 256 (93.4) | 1.00 (reference) | 1.00 (reference) | ||
| AA | 13 (4.5) | 18 (6.6) | 1.498 (0.720-3.119) | 0.280 | 0.979 (0.361-2.659) | 0.967 |
OR: odds ratio; CI: confidence interval. ∗Adjusted for age, gender, BMI, smoking history, FBG, and dyslipidemia.