Table 4.
Association between SOCS3 rs8064821 C>A polymorphism and hypertension risk in combined subjects.
| Models | Genotypes | Control, n = 569 (%) | Hypertension, n = 522 (%) | Unadjusted OR (95% CI) | P value | Adjusted OR∗ (95% CI) | Adjusted P value∗ |
|---|---|---|---|---|---|---|---|
| rs8064821 C>A | HWE = 0.786 | HWE = 0.368 | |||||
| Additive | CC | 358 (62.9) | 273 (52.3) | 1.00 (reference) | 1.00 (reference) | ||
| CA | 188 (33.0) | 212 (40.6) | 1.479 (1.150-1.902) | 0.002 | 1.821 (1.276-2.600) | 0.001 | |
| AA | 23 (4.1) | 37 (7.1) | 2.110 (1.225-3.634) | 0.007 | 2.143 (1.042-4.410) | 0.038 | |
| Dominant | CC | 358 (62.9) | 273 (52.3) | 1.00 (reference) | 1.00 (reference) | ||
| CA/AA | 211 (37.1) | 249 (47.7) | 1.548 (1.215-1.971) | <0.001 | 1.863 (1.326-2.619) | <0.001 | |
| Recessive | CC/CA | 546 (95.9) | 485 (92.9) | 1.00 (reference) | 1.00 (reference) | ||
| AA | 23 (4.1) | 37 (7.1) | 1.811 (1.061-3.091) | 0.029 | 1.696 (0.839-3.428) | 0.141 |
OR: odds ratio; CI: confidence interval. ∗Adjusted for age, gender, BMI, smoking history, FBG, and dyslipidemia.