TABLE 2.

Prognostic Factors for Clinical Worsening in CTD-PAH

	Baseline Assessment				Final Assessment
	Univariate Analysis		Multivariate Analysis		Univariate Analysis		Multivariate Analysis
	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value
Clinical worsening
mPAP					1.07 (1.01–1.14)	0.022	1.15 (1.01–1.31)	0.027
Hb	0.53 (0.36–0.79)	0.002	0.54 (0.36–0.80)	0.002
ESR 60 min					1.03 (1.01–1.05)	0.011	1.05 (1.01–1.09)	0.007
qR					4.24 (1.17–15.45)	0.028	0.03 (0.00–0.33)	0.004

qR patterns in ECG. See Supplementary Table 3 for all statistic results.