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. 2021 Nov 10;599(7886):622–627. doi: 10.1038/s41586-021-04066-1

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© The Author(s) 2021, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — a) A snapshot of steps and parameters used to estimate the mutation burden and fixed deleterious alleles. b) Variant annotation using SIFT revealed higher non-synonymous mutations, of which non-synonymous deleterious variants were used to identify deleterious mutations. c) Mutation burden analysis indicated a 17.88% decrease (two-tailed Welch’s t-test; t = 2.525, df = 27, p = 0.01772, CI = 95%) in mutation burden in cultivated (n = 2987) as compared to progenitor (C. reticulatum; n = 28). d) Mutation burden for genomic regions under selection showed that landraces (n = 2439) contained 206.91% higher (two-tailed Welch’s t-test, t = −17.087, df = 1645, p = 2.195676 × 10⁻⁶⁰, CI = 95%) deleterious mutations than breeding lines (n = 396). The black solid dots in box plots represent mean values for the respective population. Each of the box plots shows the upper and lower whisker, the 25% and 75% quartiles, the median (as solid line) and the mean (black dot)

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