Fig. 5. Sensory receptor gene clusters preferentially belong to B compartments in brain cells and form megabase-range interactions.
a, Selected top enriched GO terms for genes that increase expression in all brain cells relative to mES cells and move from compartment B in mES cells to compartment A in brain cells (pink box), and for genes that decrease expression in brain cells and move to compartment B compared to mES cells (blue box). All enriched GO terms had one-sided Fisher’s exact permuted P = 0. b, Top enriched GO terms for genes silent in all cell types that gain membership to compartment B in brain cells. Most genes are Olfr and Vmn sensory receptor cluster genes. All enriched GO terms had one-sided Fisher’s exact permuted P = 0. c, GAM contact matrices containing Vmn and orphan receptor genes (chromosome 7: 35–55 Mb) show large clusters of strong interactions between B compartments in OLGs, PGNs and DNs, but not mES cells. Dashed boxes indicate interacting regions.