Table 2.
Biological processes and phenotypes associated with cis-eQTL candidate genes. Retrieved from ensembl.org. Copyright 2020.
| Gene | Chr | Biological process | Phenotype |
|---|---|---|---|
| Xkr9 | 1 | Apoptosis | Prostatic neoplasms |
| Eya1 | 1 | Kidney, eye, and ear development | Branchio-oto-renal syndrome |
| Msc | 1 | Regulation of transcription by RNA polymerase II | Adolescent idiopathic scoliosis; Alzheimer disease |
| Mapkbp1 | 2 | Negative regulation of interleukin-8 production | Nephronophthisis |
| Pla2g4d | 2 | Glycerophospholipid catabolic process | - |
| Ltk | 2 | Signal transduction | Type 2 diabetes |
| Rpap1 | 2 | Transcription by RNA polymerase II | - |
| Pla2g4f | 2 | Phospholipid metabolic process | Stroke |
| Vps39 | 2 | Late endosome to lysosome transport | Breast neoplasms; Schizophrenia |
| Tmem87a | 2 | - | Stroke |
| Ganc | 2 | Carbohydrate metabolic process | - |
| Zfp106 | 2 | - | Amyotrophic lateral sclerosis |
| Tgm5 | 2 | Peptide cross-linking | Peeling skin syndrome |
| Ccndbp1 | 2 | Regulation of cell cycle | - |
| Adal | 2 | Nucleotide metabolic process | Thrombocytopenia |
| Trp53bp1 | 2 | DNA damage checkpoint | Thymus hypoplasia |
| Tubgcp4 | 2 | Cytoplasmic microtubule organization | Autosomal recessive chorioretinopathy-microcephaly syndrome |
| Adcy8 | 15 | Adenylate cyclase-activating G protein-coupled receptor signaling pathway | Chronic kidney disease; myocardial infarction |
| Olig1 | 16 | Regulation of transcription, DNA-templated | Albuminuria |
| Ifnar2 | 16 | Cell surface receptor signaling pathway | Immunodeficiency |
| Gpr89 | 3 | Ion transmembrane transport | Autism spectrum disorder; Schizophrenia |
| Cd160 | 3 | Regulation of adaptive immune response | Schizophrenia |
| Fmo5 | 3 | Oxidation-reduction process | Autism spectrum disorder; chromosome 1q21.1 deletion syndrome |
| Chd1l | 3 | Nucleotide-excision repair, preincision complex assembly | Congenital anomalies of kidney and urinary tract; type 2 diabetes |
| Pde4dip | 3 | Cellular protein-containing complex assembly; regulation of Golgi organization | Breast, central nervous system, gastrointestinal, and skin tumors |
| Ankrd34a | 3 | - | - |
| Rbm8a | 3 | RNA processing | Thrombocytopenia-absent radius syndrome |
| Pex11b | 3 | Peroxisome proliferation | Peroxisome biogenesis disorder; neonatal adrenoleukodystrophy; infantile refsum disease |
| Sv2a | 3 | Chemical synaptic transmission; regulation of gamma-aminobutyric acid secretion; cellular calcium ion homeostasis | Seizures |
| Mtmr11 | 3 | Phosphatidylinositol dephosphorylation | Adolescent idiopathic scoliosis |
| Hist2h2ac | 3 | DNA binding | - |
| Hist2h2be | 3 | Antibacterial humoral response; negative regulation of tumor necrosis factor-mediated signaling pathway | - |
| Prpf3 | 3 | RNA binding | Retinitis pigmentosa |
| BC028528 | 3 | - | - |
| Aph1a | 3 | Notch receptor processing; beta-amyloid precursor protein | Bipolar disorder; schizophrenia |