Table I. Multiple logistic regression model shows selective SH2B3 SNP (rs3184504) association with reduced mortality in sepsis cohort.

Single Nucleotide Polymorphisms (SNP) within 2kB of the coding region of SH2B3 were analyzed for association with sepsis mortality. Data from the identification of SNPs Altering ALI Risk (iSPAAR) consortium Caucasian subjects with sepsis (n=1542 total subjects) were analyzed for inpatient sepsis mortality displayed by genotype and error illustrated by the adjusted p value from the multiple logistic regression model for sepsis inpatient mortality adjusted for age and gender.

SNP	Adj p**	P-Value	OR**	OR 95% low CI**	OR 95% hi CI**	N	Bonferroni P	FDR
rs2239196 (intron)	0.5749	0.626	1.15	0.7111	1.858	1543	1	0.575
rs2239194 (intron)	0.4315	0.532	1.15	0.815	1.622	1543	1	0.575
rs3184504 (exon)	0.0054	0.01	0.755	0.618	0.921	1542	0.022	0.022
rs739496 (intron)	0.1195	0.16	1.201	0.956	1.51	1542	0.478	0.236

^**adjusted for age, gender (age is associated with mortality)