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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: J Immunol. 2021 Nov 5;207(11):2785–2798. doi: 10.4049/jimmunol.2100107

Figure 1. Beta-glucan augments innate immune defense against P. aeruginosa in mice.

Figure 1.

(A) C57Bl/6 mice were injected i.p. with β-glucan (1 mg) or vehicle on 2 consecutive days at 1, 3, 7 and 14 days prior to i.p. inoculation with 108 CFU P. aeruginosa with harvest of plasma and peritoneal lavage fluid 6 hours after infection. (B) Core (rectal) body temperature in vehicle- or β-glucan-treated mice. (C) CFUs of P. aeruginosa per mL of peritoneal fluid. (D-F) Number of monocytes (D), neutrophils (E), or macrophages (F) in infected vehicle- or β-glucan-treated mice. Body temperature and clearance data shown as median. All other data shown as mean ± SEM. N = 10-20 mice per group. * p<0.05, ** p<0.01, *** p<0.001, **** p<0.0001 by Mann-Whitney U test (B, C) or ANOVA with Tukey’s post-hoc multiple comparison test (D-F).