Table 7.

Frequency of molecular monitoring in case of stable and unstable MR4.5 maintained during the first 6 months after discontinuation. After month 6, patients with unstable MR4.5 must be monitored at closer intervals than those with a stable MR4.5. When personalizing the frequency of monitoring, it is important to consider the turnaround time (TAT) of the reference lab

Months after TKI cessation	MR4.5 up to month 6
	Stable	Unstable
0–6	Monthly	Monthly
7–12	Every 2–3 months	Every 1.5–2 months
> 12	Every 4 months	Every 3 months

TKI tyrosine-kinase inhibitor, MR4.5 molecular response defined as a 4.5-log decrease in BCR-ABL1 transcript based on the International Scale, Stable MR4.5 up to month 6 confirmed MR4.5 in all QPCR tests performed in the first 6 months after discontinuation