A population cellular kinetic model of lisocabtagene maraleucel (liso-cel), a CD19-directed chimeric antigen receptor T-cell product, was developed to characterize the kinetics of the liso-cel transgene in relapsed/refractory large B-cell lymphoma.

Liso-cel cellular kinetics were well described by a piecewise model of cellular growth kinetics that featured lag, growth, and biphasic decay phases.

The covariates tested were not considered to have a meaningful impact on liso-cel kinetics.