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. 2021 Nov 24;11:22860. doi: 10.1038/s41598-021-02297-w

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© The Author(s) 2021

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(A) Front and back highlight of the viral Spike protein (orange) binding to glycated ACE2 receptor (blue). The lysine amino acid residues subjected to glycation on ACE2 receptor are labelled in the image. (B) Difference in the distances between the first two cases considered. On the left: the classical interaction in PDB 6M0J, in which the distance between the carbonyl oxygen atoms of ACE2 receptor (green) HIS34 and Spike protein RBD (violet) SER494 is 6.01 Å. On the right: the interaction between glycated ACE2 receptor (blue) and native Spike protein RBD (orange). In this case, the distance between the carbonyl oxygen of ACE2 receptor (blue) HIS34 and Spike protein RBD (orange) SER494 is 9.16 Å.