Fig. 3. Genes associated with isoniazid resistance follow definite functional patterns.
a Classification of all genes and intergenic regions in the M. tuberculosis genome according to the effect of insertions on resistance. Essential genes were obtained from DeJesus et al.13. b Genes associated with increased sensitivity were enriched in cell envelope genes (n = 130), whereas those associated with increased resistance were enriched in energy metabolism genes (n = 329). c Oxidoreductases were even more enriched in the final candidates than they were in the genes detected with functional genomics (n = 57 and 459). d Cell wall biosynthesis genes were enriched in features associated to resistance both functionally and phylogenetically to resistance.