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. 2021 Nov 24;12:6822. doi: 10.1038/s41467-021-27164-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The Venn diagram displays the overlap in protein targets captured by the SomaScan assay and the Olink proximity extension assay (PEA). Modes of binding to the protein target are depicted simplified next to each ellipse. Correlation coefficients were used to compare both technologies and factors possibly accounting for measurement differences and low correlation coefficients examined in a subset of 485 individuals with overlapping measurements. For the set of 871 common protein targets, genome-wide association analysis was performed in 10,708 (SomaScan assay) and 485 (Olink PEA) participants in the Fenland cohort. Correspondence of genetic associations was analysed by examining local genetic architecture, comparison of effect estimates and evaluation of phenotypic consequences. Parts of this figure have been created with BioRender.com.