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. 2021 Nov 24;12:6821. doi: 10.1038/s41467-021-27106-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Frequency of microsatellite instability high (MSI-H) by cohort (Nigerian, The Cancer Genome Atlas [TCGA], Memorial Sloan Kettering Cancer Center [MSKCC]). MLH1 methylation, BRAF V600E mutation, and CpG island methylator phenotype (CIMP) frequencies are shown for MSI-H patients. b Methylation data from Nigerian patients are presented along with CIMP classification (i.e., high [CIMP-H] n = 2, low [CIMP-L] n = 5, non-CIMP n = 18) and MSI status (i.e., stable [MSS] n = 18, high [MSI-H] n = 7). c Frequency of oncogenic signaling pathway alterations in Nigerian and MSKCC MSI-H tumors (n = 18), with MSKCC patients stratified by African American and non-African American ethnicity. d Oncoprint of BRAF V600E and mismatch repair (MMR) genomic alterations (MLH1, MSH2, MSH6, PMS1) in MSI-H Nigerian specimens is presented with sex, location of primary, total mutational burden (TMB), methylation status, CIMP classification, and MSIsensor score.