Table 2.
Clinicopathologic comparison by MSI status.
| MSKCC | Nigeria | P valuea | |||
|---|---|---|---|---|---|
| MSI-H (n = 106) | MSS (n = 997) | MSI-H (n = 18) | MSS (n = 46) | ||
| Median age at diagnosis, years (range) | 60.0 (20.0–85.0) | 54.0 (13.0–93.0) | 57.1 (31.4–84.6) | 58.2 (27.7–83.3) | 0.57 |
| Sex | |||||
| Female | 44 (41.5) | 461 (46.2) | 4 (22.2) | 22 (47.8) | 0.15 |
| Male | 62 (58.5) | 536 (53.8) | 14 (77.8) | 24 (52.2) | |
| Location | |||||
| Left | 23 (21.9) | 462 (47.0) | 5 (27.8) | 8 (17.4) | REF |
| Rectum | 9 (8.6) | 247 (25.1) | 1 (5.6) | 30 (65.2) | 0.03 |
| Right | 73 (69.5) | 274 (27.9) | 12 (66.7) | 8 (17.4) | 0.30 |
| Unknown | 1 | 14 | 0 | 0 | |
| Mucin | |||||
| No | 43 (56.6) | 619 (86.5) | 6 (33.3) | 32 (72.7) | 0.90 |
| Yes | 33 (43.4) | 97 (13.5) | 12 (66.7) | 12 (27.3) | |
| Unknown | 30 | 281 | 0 | 2 | |
| Stageb | |||||
| I | 7 (6.6) | 34 (3.4) | 0 (0) | 0 (0) | 0.03 |
| II | 40 (37.7) | 91 (9.1) | 3 (16.7) | 5 (10.9) | |
| III | 39 (36.8) | 228 (22.9) | 6 (33.3) | 10 (21.7) | |
| IV | 20 (18.9) | 644 (64.6) | 9 (50.0) | 31 (67.4) | |
| Location of metastatic diseasec | |||||
| Liver | |||||
| No | 9 (45.0) | 105 (16.3) | 8 (88.9) | 21 (67.7) | 0.93 |
| Yes | 11 (55.0) | 539 (83.7) | 1 (11.1) | 10 (32.3) | |
| Lung | |||||
| No | 19 (95.0) | 550 (85.4) | 8 (88.9) | 21 (67.7) | 0.92 |
| Yes | 1 (5.0) | 94 (14.6) | 1 (11.1) | 10 (32.3) | |
| Peritoneal | |||||
| No | 14 (70.0) | 539 (83.7) | 4 (44.4) | 18 (58.1) | 0.79 |
| Yes | 6 (30.0) | 105 (16.3) | 5 (55.6) | 13 (41.9) | |
| Other | |||||
| No | 14 (70.0) | 496 (77.0) | 9 (100) | 30 (96.8) | >0.95 |
| Yes | 6 (30.0) | 148 (23.0) | 0 (0) | 1 (3.2) | |
| Median overall survival, months (95% CI) | NR (NR–NR) | 69.1 (59.9–83.2) | 32.1 (8.5–NR) | 4.8 (2.1–10.6) | 0.15 |
Data are n (%) unless noted.
MSKCC Memorial Sloan Kettering Cancer Center, MSI-H microsatellite instability high, MSS microsatellite stable, CI confidence interval, NR not reported.
aThe covariates included the main effects molecular subtype and center and an interaction term of the two. A linear model was used for age, a logistic model for gender, mucin, stage, location of metastatic disease, a multinomial model for location of primary, and a Cox model for overall survival. P values by Wilcoxon rank-sum test for continuous variables, Fisher’s exact test for categorical variables, and log rank test for overall survival.
bThe comparison is stage I, II, III vs. IV.
cIn the subset of patients presenting with stage IV.