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. 2021 Nov 24;11:22887. doi: 10.1038/s41598-021-02360-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cerebral thrombus formation occurs after development of infarcts following tMCAO. (A) Representative images of brain sections stained with TTC to visualize infarcts. Each timepoint shows three consecutive brain sections from one mouse. White: Infarct, Red: viable tissue. (B) Edema corrected quantification of infarct sizes. Data is plotted using GraphPad Prism 7.05 (https://www.graphpad.com) depicted as mean ± SD and each dot represents one mouse. N = 7–8 per time point. (C–F) 3D reconstruction of the ipsilateral hemispheres of mice after (C) sham surgery, (D) 4 h of reperfusion, (E) 8 h of reperfusion or (F) 24 h of reperfusion. Vessels (CD105/CD31; red), platelets (GPIX; green). 3D reconstructions were generated using Biptlane Imaris 9.6 (https://imaris.oxinst.com/); grid size: 0.5 mm. Statistical differences were analyzed using two-tailed Mann–Whitney U test. P-values < 0.05 were considered statistically significant. Compared to sham, differences to all other groups are highly significant with P < 0.001.