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. 2021 Nov 24;11:22818. doi: 10.1038/s41598-021-02241-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cell number and proliferation after incubation with cNPs. (A) Cell number was measured by Cell Counting Kit-8 (CCK8) assay after 24 h of cNP addition. Colon26, NIH3T3, and RAW264.7 cells were incubated with 5–1000 μg/mL of cNPs. Results are expressed as the mean ± SD of four samples. *p < 0.05 vs. 0 μg/mL cNP group (the control group). (B) Cell proliferation was measured by CCK8 assay after 6, 12, 24 and 48 h of 1000 μg/mL cNP addition. Results are expressed as the mean ± SD of four samples. *p < 0.05 vs. control group.