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. 2021 Nov 24;11:22818. doi: 10.1038/s41598-021-02241-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Combined effect of cNPs and RAW264.7 cells on the proliferation of colon26/fluc cells. (A) Co-incubation of RAW264.7 cells with colon26/fluc cells with or without cNPs. After 24 h-incubation, cells were lysed, and luciferase activity was measured. Results are expressed as the mean ± SD of three samples. *p < 0.05 vs. without cNP (no treatment) group. (B) Colon26/fluc cells were seeded onto the bottom of Transwell, and RAW264.7 cells with or without cNPs were added to the insert well (upper bottom). After 24 h-incubation, colon26/fluc cells were lysed and luciferase activity was measured. Results are expressed as the mean ± SD of three samples. *p < 0.05 vs. control group.