Figure 7.
Tumor growth suppression in tumor-bearing mice after cNP administration. (A) Tumor size in tumor-bearing mice. Colon26 cells were subcutaneously injected into the back area of BALB/c mice. After the tumor size reached 50 mm3, cNPs at concentrations of 1000 or 3000 μg/mL (50 μL) were intratumorally administered every day. Results are expressed as the mean ± SD of three mice. *p < 0.05 vs. PBS group. (B) Body weight changes in different treatment groups. The change of body weight in tumor-bearing mice after cNP treatment. Results are expressed as the mean ± SD of three mice. *p < 0.05 vs. PBS group. (C) Skin inflammation in mice after cNP administration. 1000 or 3000 μg/mL cNPs, alum, and PBS (50 μL) were subcutaneously administered into the back area of BALB/c mice. After 24 h, the skin was observed. Scale bars indicate 5 mm.