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. 2021 Nov 24;12:6824. doi: 10.1038/s41467-021-27123-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a The free energy profiles of droplet coalescence at various nucleolar particle-chromatin interactions. The result for ϵ = 1.8 is identical to the one presented in Fig. 3. Error bars were calculated as standard deviation of the mean using block averaging by dividing the simulation trajectories into five blocks of equal length. b Number of droplets formed at the end of 12 independent dynamical simulations at various strengths of nucleolar particle-chromatin interactions. Error bars correspond to standard deviations of results from independent trajectories. c The maximum number of clusters observed in dynamical trajectories performed at various nucleolar particle-chromatin interactions. d The fraction of cluster switching events following the Brownian motion-induced coalescence (BMC, blue) and the diffusion-limited Ostwald ripening (DOR, red) at various nucleolar particle-chromatin interactions.