Table 5.
Univariable and multivariate analyses of factors associated with a non-immune cause in the subgroup of patients with ARF complicating a known Svv (n = 70)a
| Immune ARF (n = 14) | Non-immune ARF (n = 56) | Univariable analysis | p | Multivariate analysis | p | |
|---|---|---|---|---|---|---|
| OR [95% CI] | OR [95%CI] | |||||
| Immunosuppression | 7 (50) | 50 (89) | 8.33 [2.17–32.05] | 0.002 | 9.41 [1.52–58.3] | 0.016 |
| Severe chronic renal failure, n (%) | 3 (21) | 25 (45) | 2.95 [0.74–11.76] | 0.124 | NR | 0.33 |
| Time from Svv diagnosis to ICU admission, months | 21 [8–60] | 56 [9.5–132] | 1.009 [0.999–1.020]b | 0.084 | NR | 0.099 |
| BVAS (Birmingham Vasculitis Activity Score) | 17.5 [8–21] | 0 [0–6] | 0.85 [0.78–0.92]b | < 0.0001 | 0.84 [0.77–0.93] | < 0.0001 |
| Time from resp. symptoms to ICU admission, < 3 days | 4 (29) | 31 (55) | 3.10 [0.87–11.07] | 0.082 | NR | 0.13 |
NR not retained in the model at the p = 0.05 significance level
aIncluding the second admission only in the 9 patients with 2 ICU admissions
bPer unit (per month since the diagnosis of ARF or per BVAS point)