Table 1.

Inhibition data against P. aeruginosa RmlA for analogues 1a – 1f.

Entry	Compd.[a]	R1	R2	% Inhibition at 10 μM	IC50 (μM)[b]
1	1a	4-BrC6H4	H	100	0.034 ± 0.002
2	1b	4-BrC6H4	(CH2)3NHCH3	100	0.860 ± 0.096
3	1c	4-BrC6H4	(CH2)2NHCH3	0	–
4	1d	4-BrC6H4	(CH2)4NH2	100	0.303 ± 0.026
5	1e	4-BrC6H4	(CH2)5NH2	100	0.316 ± 0.023
6	1f	Ph		100	2.470 ± 0.020

[a] The following PDB codes are assigned to structures of the complexes of RmlA bound to 1b (6TQG), 1d (6T38), 1f (6T37); [b] SD, standard deviation (n = 3).