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. 2021 Nov 12;23(1):42. doi: 10.3892/etm.2021.10964

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Copyright: © Lan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of lidocaine on OGD/R-induced neuronal cell apoptosis. Cerebral cortical neurons were subjected to OGD/R and then treated with 10 µg/ml lidocaine or saline. Cells were divided into four groups: i) Control; ii) OGD/R; iii) OGD/R + saline; and iv) OGD/R + lidocaine. The proportion of apoptotic neurons was (A) determined by flow cytometry and (B) quantified. Protein expression were (C) determined by western blotting and semi-quantified for (D) the ratio of Bax/Bcl-2 and (E) Bcl-xl. (F) The relative caspase-3 activity. ^**P<0.01 vs. control; ^##P<0.01 vs. OGD/R + saline. OGD/R, oxygen-glucose deprivation/reoxygenation; PI, propidium iodide.