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. 2021 Nov 10;93(46):15340–15348. doi: 10.1021/acs.analchem.1c02896

Figure 1.

Figure 1

Results of LC–MS/MS analysis of PDE plasma samples. (a) Plot of the sum of feature A (m/z 186.1123, 2.33 min RT) and feature B (m/z 186.1123, 2.55 min RT) in the plasma of 26 controls (gray) and 11 PDE patients (orange). Each sample was analyzed as two technical replicates, shown as consecutive bars in the figure. All values are normalized on the value in a quality control sample. (b) CID MS/MS spectrum of feature A in one of the PDE patient plasmas. A scheme showing the hypothesized core structure of features A and B and their fragmentation to the m/z 128.0707 fragment is inlaid in the figure.