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. 2021 Nov 25;40:373. doi: 10.1186/s13046-021-02186-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — DNA hypermethylation represses ELP5 expression in GBC. a Relative expression of ELP5 in GBC tumorous tissues normalized to matched normal tissues. b Statistical analysis of ELP5 expression in GBC tumorous tissues and matched normal tissues. Paired student’s t test for statistical analysis, **P < 0.01. c Statistical analysis of ELP5 expression in GBC tissues with different DNA copy numbers. One-way ANOVA test for statistical analysis, ns, not significant. d Schematic diagram of CpG islands on ELP5 promoter region around transcription start site (TSS). e Correlation analysis between the promoter methylation levels and transcription levels of ELP5 in GBC tissues, detected by methylation-specific quantitative PCR (MS-qPCR) and real-time quantitative PCR (RT-qPCR), respectively. f Correlation analysis between the contents of 5mC in promoter and transcription levels of ELP5 in GBC tissues, detected by anti-5mC chromatin immunoprecipitation (ChIP)-qPCR and MS-qPCR, respectively