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. 2021 Nov 25;40:373. doi: 10.1186/s13046-021-02186-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — DAC sensitizes GBC cells to gemcitabine in vivo. a Experiment timeline and dosing schedule for xenograft models. b Western blot for ELP5 protein levels in NOZ xenograft tumours undergoing different treatments. c Tumour growth curves in NOZ xenograft models. d Statistical analysis of tumour weight in NOZ xenograft tumours after scarification. e Representative images of NOZ xenograft tumours after scarification. f Tumour growth curves in GBC-SD xenograft models. g Statistical analysis of tumour weight in GBC-SD xenograft tumours after scarification. h Representative images of GBC-SD xenograft tumours after scarification. i Representative immunohistochemistry of ELP5 proteins in paraffin-fixed NOZ xenograft tissues. Scale bar = 100 μm. One-way ANOVA test for statistical analysis, ns, not significant, **P < 0.01, ***P < 0.001