Fig. 1.
A structural representation of the homo-dimeric nature of SARS-CoV-2 Mpro. The structural domains (I-III) are shown in red, royal blue and orange cartoons, respectively. The N-finger region (residue 1–9) and the long loop connecting domain II to III (linker) are colored cyan and green, respectively. The substrate-binding pocket and allosteric pocket on a monomer are illustrated in grey and pink wireframe and dotted lines, respectively. The distribution of SARS-CoV-2 Mpro mutations identified from the GISAID database [72] is labeled on the structure. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)