Fig. 3.

Heat maps for the potential hubs according to the global top 5% for each of the five DRN metrics, for the reference protein in the apo and the six allosterically bound states. Detected hubs are annotated with their centrality values, while their homologous residues in alternate samples are not, but are only shown for the sake of comparison. For each metric, low to high centrality values are colored white, through yellow, orange and red to black. Measurements for the ligand-bound protomer (chain A) have been systematically presented on the left side, while those of the unbound protomer are on the right – this does not apply to the apo state. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)