Fig. 11.

Averaged Katz centrality hubs represented as a networks for both the apo state and the six allosterically-bound complexes. Each of the sub-figures represents the subnetwork obtained for each of the allosterically bound ligands, namely (A) SANC00302, (B) SANC00303, (C) SANC00467, (D) SANC00468, (E) SANC00469 and (F) SANC00630, when merged with the apo protein, in each case. Red, orange, blue and green nodes (and edges) depict the protomers (apo chains A and B, and complex chains A and B, respectively) to which a hub belongs. Each node is also sized by its score – i.e. the number of edges it holds. Hubs that are present in all 4 protomers are in purple. Score 2 loss and gains from the reference are colored yellow and cyan, respectively. Score 1 losses and gains are colored brown. Inconclusive hubs are in grey. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)