Fig. 13.

Heat map for the potential hubs according to the global top 5% for the averaged EC metric for the reference and 50 mutant proteins in allosterically bound state to SANC00302 and SANC00468. Detected hubs are annotated with their centrality values, while their homologous residues in alternate samples are not, but are only shown for the sake of comparison. Low to high centrality values are colored white, through yellow, orange and red to black. Mutants demonstrating highly different centrality hub profiles are marked with red boxes. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)