Table 1.
Hub combination possibilities for any given residue between two dimers. A tick symbol (✓) denotes the presence of a hub from a given protomer, while a cross (x) denotes absence of that same hub from a chain. Apo - A: Apo protein, protomer A; Apo - B: Apo protein, protomer B; Complex A: Protomer A of protein–ligand complex; Complex B: Protomer B of protein–ligand complex.
| Apo - A | Apo - B | Complex A | Complex B | Score | Interpretation | |
|---|---|---|---|---|---|---|
| 1 | ✓ | x | x | x | 1 | Potential ligand effect inferred by asymmetry |
| 2 | x | ✓ | x | x | 1 | Potential ligand effect inferred by asymmetry |
| 3 | x | x | ✓ | x | 1 | Potential ligand effect inferred by asymmetry |
| 4 | x | x | x | ✓ | 1 | Potential ligand effect inferred by asymmetry |
| 5 | ✓ | ✓ | x | x | 2 | Complete hub loss: ligand effect |
| 6 | x | ✓ | ✓ | x | 2 | Inconclusive effect |
| 7 | x | x | ✓ | ✓ | 2 | Hub gain on ligand presence |
| 8 | ✓ | x | ✓ | x | 2 | Inconclusive effect |
| 9 | ✓ | x | x | ✓ | 2 | Inconclusive effect |
| 10 | x | ✓ | x | ✓ | 2 | Inconclusive effect |
| 11 | ✓ | ✓ | ✓ | x | 3 | Potential ligand effect inferred by asymmetry |
| 12 | x | ✓ | ✓ | ✓ | 3 | Potential ligand effect inferred by asymmetry |
| 13 | ✓ | x | ✓ | ✓ | 3 | Potential ligand effect inferred by asymmetry |
| 14 | ✓ | ✓ | x | ✓ | 3 | Potential ligand effect inferred by asymmetry |
| 15 | ✓ | ✓ | ✓ | ✓ | 4 | No ligand effect from symmetry |
| 16 | x | x | x | x | 0 | Not applicable |