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. 2021 Jun 2;70(4):459–468. doi: 10.1538/expanim.21-0005

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©2021 Japanese Association for Laboratory Animal Science

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)

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Fig. 1. — Eye phenotypes in Map3k1^L314Q/+ mice. (A and B) Appearance of the wild-type (A) and Map3k1^L314Q/+ (B) eyes at week 8. Corneal opacity was observed in the Map3k1^L314Q/+ mice. (C, D) Hematoxylin and eosin staining of frontal eye sections from wild-type (C) and Map3k1^L314Q/+ (D) mice. In Map3k1^L314Q/+ mice, the epithelium was markedly thickened and contained an eosinophilic stratum corneum. (E, F) Appearance of the eyes in wild-type (E) and Map3k1^L314Q/+ (F) mice. Map3k1^L314Q/+ mice are born with open eyelids. (G, H) HE staining of the coronal eye sections from wild-type (G) and Map3k1^L314Q/+ (H) mice at postnatal day 0 (P0). Scale bar=100 µm.