Figure 5.

Membership grades for two-target combinations. Membership grades of cell viability (${\eta }_{CV}$), metabolic deviation (${\eta }_{DV}$), and side effect (${\eta }_{SE}$) for two-target combinations of anticancer enzymes for colon cancer treatment. Cancer cell cytotoxicity was observed for each treatment. Therefore, the cell viability grade represents the cell growth viability of normal cells during treatment. Higher metabolic deviation grades indicate that the flux pattern of the perturbed cells was more dissimilar to the cancer template and more similar to the normal template. Higher side effect grades indicate fewer side effects. The numbers of drugs identified from DrugBank acting on each first target are shown in Table 2. The numbers of drugs acting on second targets are listed in brackets as follows: GAPDH (7), PGK1 (6), ENO1 (6), RPIA (1), BPGM (Not Available), and PCK1 (6). Error bar around each estimate was obtained through ten repeated executions.