Figure 6.

Mean fold changes of metabolite-flows for perturbed cases and the template. The ${log}_2$ fold changes of metabolite-flows for the identified targets in (A) the first group and (B) the second group. The identified gene-encoding enzymes are represented in red. The identified antimetabolites are presented in gray. The values in yellow boxes denote ${log}_2$ fold changes of metabolite-flows ${log}_2(r_m^{CA}/r_m^{BL})$ for the template, whereas the green box displays ${log}_2(r_m^{M{U}_a}/r_m^{BL})$ for each perturbation. A positive value indicates that the metabolite-flow of cancer cells or the perturbation is higher than basal. A negative value represents lower flow.