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. 2021 Oct 29;10(11):1115. doi: 10.3390/biology10111115

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Membership grades for two-target combinations. First and second factor loadings of the identified anticancer target genes and antimetabolites. The template is the green dot. The first group around Factor 1 in the red circle contained 116 two-target combinations and a three combination of (PTDSS1, PTDSS2, ENO1) comprising anticancer target genes and antimetabolites. The second group around Factor 2 contained 42 anticancer target genes and antimetabolites. Half of these were two-target combinations. These two-target combinations included the enzyme PCK1.