Table 3.

Membership grades of cell viability (${\eta }_{CV}$), metabolic deviation (${\eta }_{DV}$), and side effect (${\eta }_{SE}$) for the top 10 one-target antimetabolites determined by the IACT framework.

Metabolite	Symbol	${\mathit{\eta }}_{\mathbf{CV}}$	${\mathit{\eta }}_{\mathbf{DV}}$	${\mathit{\eta }}_{\mathbf{SE}}$	Subclass
Hydroxymethylglutaryl Coenzyme A	hmgcoa	0.712	0.668	0.636	Fatty acyl thioesters
Mevalonate	mev-R	0.719	0.674	0.637	Fatty acids and conjugates
Orotate	orotsumpplementation	0.718	0.673	0.637	Pyrimidines and pyrimidine derivatives
Deoxythymidine-5${}^{\prime }$-Phosphate	dtmp	0.719	0.665	0.635	Pyrimidine deoxyribonucleotides
Uridine-5${}^{\prime }$-Monophosphate	ump	0.701	0.67	0.626	Pyrimidine ribonucleoside monophosphates
Phosphatidylethanolamine	pe-hs	0.795	0.691	0.7	Glycerophospholipids
L-Glutamate	glu-L	0.783	0.663	0.675	Amino acid
L-Serine	ser-L	0.789	0.656	0.672	Amino acid
N-Acylsphingosine	crm-hs	0.75	0.664	0.665	The parent compounds of the ceramide family
Sphingomyelin	sphmyln-hs	0.75	0.655	0.658	Phosphosphingolipids, fatty acyl group