Figure 2.

Schematic diagram suggesting several negative factors (conventional and nonconventional) that influence the seeding of the gut microbiota (as identified by “omics” approaches) in the early days of life of the infant and that can anticipate the onset of AD and PD. In addition to searching for the negative factors influencing ND, in our opinion, we suggest that the search in this field should also be expanded to the features (biomarkers, epigenetic influence) that could explain those that are centenarian life spans. This diagram was also created by one of the coauthors of this review, a 76-year-old researcher suffering from PD for 12 years.