Figure 2.

ψ-GSH treatment reverses oxidative stress in the APP/PS1 model. (a) ψ-GSH treatment restored the levels of reduced GSH to NTG controls. (b) Attenuation of oxidative stress was evident from enhanced redox potential in mice after ψ-GSH treatment in both symptomatic cohorts. (c) Total oxidative stress as measured by DCFH-DA assay was also mitigated by ψ-GSH in these mice irrespective of age. (d) TBARS results are shown as the mean ± S.E.M. Statistical significance was assessed by a one-way ANOVA with Tukey’s post-hoc test. * p < 0.05, ** p < 0.01, # p < 0.001.