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. 2021 Nov 10;10(11):1796. doi: 10.3390/antiox10111796

Figure 6.

Figure 6

ψ-GSH treatment after the onset of AD-like neuropathology halts the progressive degeneration of the NAergic cortical afferent axons in symptomatic 10- and 14-mo APP/PS1 mice. (a) Representative images of TH+ axonal projections in S1BF of both the 10- and the 14-mo cohorts. Scale bar, 20 μm. (b) Quantification of TH+ axonal density in 10- and 14-mo NTG and APP/PS1 mice treated with either saline or ψ-GSH. Density estimation (μm/μm3) was determined using the Spherical probe on Stereo Investigator Software. Data are presented as mean ± S.E.M. A one-way ANOVA with Tukey’s post-hoc test was used for statistical comparisons (b). * p < 0.05, ** p < 0.01, *** p < 0.005, **** p < 0.001.