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. 2021 Nov 10;10(11):1796. doi: 10.3390/antiox10111796

Figure 7.

Figure 7

ψ-GSH treatment after the onset of AD-like neuropathology halts the progressive degeneration of the NAergic neurons of the LC in symptomatic 10 and 14-mo APP/PS1 mice. (a) Representative images of TH+ neurons of the LC in both the 10 and 14-mo cohorts. Scale bar, 100 μm. (b) Quantification of TH+ neurons in the LC in 10- and 14-mo NTG and APP/PS1 mice treated with either saline or ψ-GSH. Estimated population was determined by the Optical Fractionator probe on Stereo Investigator software. (c) Higher magnification images of the TH+ neurons in the LC. Scale bar, 50 μm. (d) Quantification of the TH+ neuronal volume in 10- and 14-mo NTG and APP/PS1 mice treated with either saline or ψ-GSH. Data are presented as mean ± S.E.M. A one-way ANOVA with Tukey’s post-hoc test was used for statistical comparisons (b,d). *** p < 0.005, **** p < 0.001.