Figure 7.

Correlative analysis of miR-182-5p and SESN2 expression on the survival rates of HNSCC patients who received radiotherapy. (A) Scatter plot showing a trend of negative correlation between hsa-miR-182-5p and SESN2 mRNA using RNA-Seq analysis in the TCGA-HNSC dataset. (B) Comparison of overall survival rates in HNSCC patients who received radiotherapy. The expression of hsa-miR-182 combined with SESN2 gene expression was stratified by three groups: hsa-miR182 high with SESN2 low, hsa-miR-182 low plus SESN2 high, and others. (C) Schematic model showing the mechanism by which the miR-182-5p/SESN2 regulatory pathway mediates radiation-induced antioxidant effects and the radiation response.