Table 4.
Incidence and severity of histopathological lesions in the experimental groups.
| Ulcer | Prevention | Treatment | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 h | 7 Days | MO-EtOH | ME-EtOH | EtOH-MO | EtOH-ME | |||||||||||||||||||
| − | + | ++ | +++ | − | + | ++ | +++ | − | + | ++ | +++ | − | + | ++ | +++ | − | + | ++ | +++ | − | + | ++ | +++ | |
| Coagulative necrosis | 0 | 1 | 1 | 3 | 0 | 2 | 2 | 1 | 2 | 2 | 1 | 3 | 1 | 1 | 3 | 2 | 0 | 0 | 3 | 2 | 0 | 0 | ||
| Congestion of blood vessel | 0 | 1 | 2 | 2 | 0 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 1 | 0 | 2 | 3 | 0 | 0 | 2 | 3 | 0 | 0 |
| Hemorrhages | 0 | 1 | 2 | 2 | 0 | 2 | 2 | 1 | 5 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 5 | 0 | 0 | 0 |
| Edema | 0 | 0 | 2 | 3 | 0 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 1 | 0 | 2 | 3 | 0 | 0 | 2 | 3 | 0 | 0 |
| Inflammatory cell infiltration | 0 | 1 | 1 | 3 | 0 | 1 | 3 | 1 | 2 | 1 | 2 | 0 | 2 | 2 | 1 | 0 | 2 | 2 | 1 | 0 | 2 | 3 | 0 | 0 |
| Wide gastric pit | 0 | 1 | 2 | 2 | 1 | 2 | 2 | 0 | 2 | 1 | 1 | 1 | 2 | 2 | 1 | 0 | 2 | 2 | 1 | 0 | 2 | 3 | 0 | 0 |
| Ulcerative gastric surface | 0 | 1 | 2 | 2 | 1 | 2 | 2 | 1 | 2 | 1 | 2 | 0 | 2 | 2 | 1 | 0 | 2 | 3 | 0 | 0 | 2 | 3 | 0 | 0 |
| Intact gastric surface | 5 | 0 | 0 | 0 | 3 | 2 | 0 | 0 | 0 | 1 | 3 | 1 | 0 | 1 | 2 | 2 | 0 | 1 | 2 | 2 | 0 | 0 | 2 | 3 |
Number of rats with lesions per total examined (5 rats per group). Severity of lesions was graded by estimating the percentage area affected in the entire section. Lesion scoring: (−) absence of the lesion = 0%, (+) mild = 5–25%, (++) moderate = 26–50%, and (+++) severe ≥50% of the examined tissue sections.