Table 2.
Antitrypanosomal activity of A. nemorosa essential oils and pure compounds. For the pure compounds, their percentages in EOs from A. nemorosa aerial parts (AP) and roots (R) are also listed just after the names of the compounds.
| Samples | EC50 | Selectivity Index (SI) |
|
|---|---|---|---|
| T. brucei (s427) | Balb3T3 | ||
| Essential oils | μg/mL | μg/mL | |
| A. nemorosa aerial parts | 1.17 ± 0.09 | 5.48 ± 0.61 | 4.65 |
| A. nemorosa roots | 2.36 ± 0.09 | 5.33 ± 0.49 | 2.25 |
| Pure compounds | μg/mL ( μM) | μg/mL ( μM) | |
| β-Pinene (1): 3% AP, 22% R | 11.4 ± 2.6 (83.7) c | >100 | >8.77 |
| β-Ocimene (2): 7,2% AP, 10.7% R | 1.1 ± 0.5 (8) b | >100 | >91 |
| p-Cymene (3): 2.2% AP, 2.8% R | 4.5 ± 1.0 (33) b | 28 ± 7 | 6.2 |
| Limonene (4): 5.7% AP, 11.5% R | 5.6 ± 1.6 (41) a | >100 | >18 |
| Myrcene (5): 40.1% AP, 19.9% R | 26.2 ± 0.44 (193) | 49.6 ± 0.64 | 1.9 |
| Farnesene (6): 4.7% AP | 0.84 ± 0.04 (4.11) | 4.09 ± 0.39 | 4.85 |
| γ-Terpinene (7): 11.6% AP, 9.2% R | >100 | >100 | - |
| Reference drug | μg/mL ( μM) | μg/mL ( μM) | |
| Suramin | 0.025 ± 0.001 (0.0147) | >5 | >262 |